Tumordiagnostik

Tests

• TKTL1-Bluttest

Antikörpermessung für die Bestimmung der TKTL1-Konzentration in Makrophagen

• Tumorstatus
  Immunolpgische Phänotypisierung der APO10- und TKTL1-Konzentration in Makrophagen incl. des lymphozytärenTumorabwehrstatus (LTS)

Literatur

• Studie Neue Möglichkeiten in der Diagnose von nicht kleinzelligen Lungenkarzinomendes Universitätsklinikums Freiburg (2011) 

Poor outcome in primary non-small cell cancers is predicted by transketolase TKTL1 expression

• Studie Therapieerfolge bereits vor der Therapie erkennen (2011)

Unabhängige Studie der Uni Mannheim

• Publikation  TKTL1 Is Activated by Promoter Hypomethylation and Contributes to Head and Neck Squamous Cell Carcinoma Carcinogenesis through Increased Aerobic Glycolysis and HIF1a Stabilization

Quelle Clinical Cancer Research, Clin Cancer Res; 16(3) February 1, 2010, doi: 10.1158/1078-0432.CCR-09-2604

• Publikation  Cancer proliferation and therapy: the Warburg effect and quantum metabolism Quelle Theoretical Biology and Medical Modelling 2010, 7:2 doi: 10.1186/1742-4682-7-2

• Publikation  Coordinated Activation of Candidate Proto-Oncogenes and Cancer Testes Antigens via Promoter Demethylation in Head and Neck Cancer and Lung CancerQuelle PLoS ONE, 1 March 2009, Volume 4, Issue 3, e4961

• Artikel  Wenn Krebszellen gären, wird’s gefährlich Quelle AZN 2/09

Poster

• A. Rotmann et al., Poster FIGO 2009:

TKTL1 – a new biomarker and its relevance in the daily gynaecological practice. (Poster)

• V. Prasad et al., Poster SNM 2010:

Transketolase-like 1 (TKTL1), a new intracellular marker for staging of non-small cell lung cancer (NSCLC): Correlation with metabolic tumor size on F-18 FDG PET/CT. [Poster]